2. Signaling Pathways
  3. PROTAC
  4. Ligands for Target Protein for PROTAC

Ligands for Target Protein for PROTAC

Target Protein-binding Moiety

Ligands for Target Protein for PROTAC

Related Products

PDF 0.95 MB

The PROTAC molecule consists of a target protein ligand and an E3 ubiquitin ligase ligand, with a linker binds them together. The ligand for target protein will lead to attachment of a PROTAC to the proteins of interest for ubiquitin and subsequent degradation.

Target proteins are usually proteins whose overexpression or accumulation may play important roles in the progress of diseases. Numbers of PROTACs have been developed to degrade kinases (such as MEK, KRAS, CDK and Bcr/Abl), transcription factors (such as p53, STAT, RAR, ER and AR), epigenetic tools (such as HDAC and BET bromodomain) and E3 ligase themselves (such as MDM2).

Ligands for Target Protein for PROTAC Related Products (510):

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-158771
    PRC1 ligand 1 2467965-59-7
    PRC1 ligand 1 is a target protein ligand of MS147 (HY-160924). PRC1 ligand 1 can be used to study cancer.
    PRC1 ligand 1
  • HY-181881
    MV78-OH
    MV78-OH is a NAMPT ligand that can be used as a target protein ligand to synthesize NAMPT-targeting PROTACs, such as PROTAC NAMPT Degrader-28 (HY-181880).
    MV78-OH
  • HY-170672
    XPO1-ligand-1 1076236-11-7
    XPO1-ligand-1 is a target protein ligand for XPO1 and can be used to synthesize PROTAC PROTAC XPO1 degrader-1 (HY-170669).
    XPO1-ligand-1
  • HY-170341
    ER ligand-6 2504914-79-6
    ER ligand-6 is a target protein ligand of PROTAC ER Degrader-14 (HY-170340).
    ER ligand-6
  • HY-175371
    RIPK1-ligand-2
    RIPK1-ligand-2 is a RIPK1 inhibitor. RIPK1-ligand-2 can be used for synthesis of PROTAC RIPK1 Degrader-1 (HY-175370).
    RIPK1-ligand-2
  • HY-158430
    CYP1B1 ligand 2 2836297-58-4
    CYP1B1 ligand 2 is a target protein ligand of PROTAC CYP1B1 degrader-2 (HY-158429). CYP1B1 ligand 2 can be used to study lung cancer.
    CYP1B1 ligand 2
  • HY-125142
    AP-24567 943319-87-7
    AP-24567 is a Ligands for Target Protein for PROTAC, which can be used for the synthesis of SB1-G-187 (HY-137342).
    AP-24567
  • HY-170330
    AR ligand-33
    AR ligand-33 is the ligand for androgen receptor, that can be used for synthesis of PROTAC AR Degrader-8 (HY-170329) as the target protein ligand.
    AR ligand-33
  • HY-145484
    PROTAC IRAK4 ligand-3 2434848-46-9
    PROTAC IRAK4 ligand-3 is a ligand for target protein for PROTAC, targeting IRAK4, can be used for synthesis of PROTAC KT-474 (HY-145483). PROTAC IRAK4 ligand-3 can be used in cancer research.
    PROTAC IRAK4 ligand-3
  • HY-45124
    3-Fluoro-desmethyl-cabozantinib 849217-50-1
    3-Fluoro-desmethyl-cabozantinib is an BCL6 ligand that can be used in the synthesis of PROTACs, such as SJF-8240 (HY-123961).
    3-Fluoro-desmethyl-cabozantinib
  • HY-163963
    IBT6A-CO-ethyne 1970122-88-3
    IBT6A-CO-ethyne is a PROTAC target protein ligand (Ligands for Target Protein for PROTACs). IBT6A-CO-ethyne can be used for synthesis IBT6A (HY-13036A).
    IBT6A-CO-ethyne
  • HY-186147
    SGI-1776-amide-C6-acid 3013618-83-9
    SGI-1776-amide-C6-acid (Compound S4) is a Target Protein Ligand-Linker Conjugate that contains a Pim inhibitor (HY-13287) and a PROTAC linker, and can recruit E3 ligase. SMARCA2 Ligand-Linker Conjugate-4 is applicable for the synthesis of PROTAC SGI-1776-VHL-02 (HY-186146).
    SGI-1776-amide-C6-acid
  • HY-170450
    AR ligand-38
    AR ligand-38 is the ligand for androgen receptor, that can be used for synthesis of PROTAC AR Degrader-9 (HY-170448).
    AR ligand-38
  • HY-170860
    CK1δ/CK1ε liagnd-1
    CK1δ/CK1ε liagnd-1 is the ligand for CK1δ/CK1ε that can be used for synthesis of CK1 PROTAC degrader AH078 (HY-170859) as the ligand for target protein.
    CK1δ/CK1ε liagnd-1
  • HY-177776
    HDAC-IN-97 149647-86-9
    HDAC-IN-97 is a PROTAC HDAC6 degrader-6that can be used for synthesis of PROTACs, such as HDAC6 degrader-6 (HY-177758). HDAC6 degrader-6 is a potent HDAC6 PROTAC degrader with anticancer activity.
    HDAC-IN-97
  • HY-180826
    USP7 ligand-2
    USP7 ligand-2 is a target protein ligand that can be used for the synthesis of PROTACs, such as PROTAC USP7 Degrader-2 (HY-180793.
    USP7 ligand-2
  • HY-159573
    Napabucasin analogue 1133287-34-9
    Napabucasin analogue is a PROTAC target protein ligand (Ligands for Target Protein for PROTACs). Napabucasin analogue can be used in synthesis Napabucasin (HY-13919).
    Napabucasin analogue
  • HY-161960
    EP300/CBP ligand 2
    EP300/CBP ligand 2 (compound S19) is a ligand targeting the bromodomain of CREB binding protein (CBP) and E1A-associated protein (EP300). EP300/CBP ligand 2 can be used as a target protein ligand in the PROTAC structure, and can be coupled to the E3 ubiquitin ligase ligand through the PTOTAC Linker to synthesize PROTAC molecules with degradation effects. For example, EP300/CBP ligand 2 can be coupled with the conjugate (E3 ubiquitin enzyme ligand + Linker) Thalidomide-NH-C10-Boc (HY-161961) to produce the PROTAC molecule dCE-2 (HY-161958).
    EP300/CBP ligand 2
  • HY-181707
    RTA ligand 1
    RTA ligand 1 is a ricin toxin A chain (RTA) ligand and can be used for the synthesis of PROTACs, such as PROTAC RTA Degrader-1 (HY-181705).
    RTA ligand 1
  • HY-161709
    FLT3/CDKs ligand-1 2452019-67-7
    FLT3/CDKs ligand-1 (Compound 14) is a ligand for target protein, which promotes the degradation of cyclin-dependent kinase (CDK) and the FMS-like tyrosine kinase 3 (FLT3), inhibits FLT3/CDK related proliferations and survivals of leukemia cells. LT3/CDKs ligand-1 can be used for synthesis of PROTAC FLT3/CDKs degrader-1 (HY-161708).
    FLT3/CDKs ligand-1